What are mitochondria and mitochondrial respiration?
Mitochondria (shown in Picture 1) are organelles in our cells which are called ’’powerhouses’’ of the cell because of their central role in energy production within the human body. The chemical energy they produce is stored in adenosine triphosphate (ATP), which is why it gained the name of the ’’energy currency’’ of the cell. This process is called mitochondrial respiration.
Picture 1. Mitochondrion
NEW STUDY – How Karnozin Extra affects mitochondrial respiration
In the most recent research on Karnozin Extra, the researchers investigated how Karnozin Extra affects mitochondrial respiration. The study was published in the International Journal of Morphology and you can read the full paper here. The study led by Dr. Popović at the Medical faculty in Novi Sad examined several aspects within mitochondrial metabolism and its relationship with Karnozin Extra.
What did the study analyze?
The researchers analyzed whether Karnozin Extra can influence mitochondrial metabolism by measuring several things:
What did the study show?
Figure 1. Cell respiration rate at different Karnozin Extra concentrations (first bar is without treatment, the second one is Karnozin Extra at 2mM, the third one is Karnozin Extra at 5mM, the fourth one is Karnozin Extra at 10mM)
Figure 2. Maximum oxidative capacity at different Karnozin Extra concentrations (first bar is without treatment, the second one is Karnozin Extra at 2mM, the third one is Karnozin Extra at 5mM, the fourth one is Karnozin Extra at 10mM)
Figure 3. Effect of Karnozin Extra on activity of complex I,II and IV (first bar is without treatment, the second one is Karnozin Extra at 2mM,
the third one is Karnozin Extra at 5mM, the fourth one is Karnozin Extra at 10mM)
Figure 4. Effect of Karnozin Extra on production of vimentin (first bar is without treatment, the second one is Karnozin Extra at 2mM, the third one is Karnozin Extra at 5mM, the fourth one is Karnozin Extra at 10mM)
What are the conclusions of the study?
As we have seen from the graphs above, Karnozin Extra acts as a booster of mitochondrial metabolism. Therefore, this paper concluded: ’’Due to the stimulation of mitochondrial energy production in normal fibroblasts, our results suggested that Karnozin EXTRA® is a potentially protective dietary supplement in the prevention of diseases with altered mitochondrial function.’’